发明名称 N-aryl-n-naphthyl methyl benzamidines - analgesics hypotensives and diuretics
摘要 <p>Title cpds. of formula (where Ar = phenyl, opt. substd. by halogen; Ar' = beta-naphthyl or phenyl opt. substd. by halogen, alkyl (1-5C) alkoxy (1-5C) or CF3). are prepd. by reaction of alpha-chloromethyl naphthalene (II) with the appropriate benzamidine in liquid ammonia in the presence of sodamide. In an example 19.6g N-phenyl benzamidine was treated with sodamide in liquid ammonia and 17.7g (II) added. There was obtained a 51% yield of (I) m.pt. 125 degrees C.</p>
申请公布号 FR2081555(A1) 申请公布日期 1971.12.10
申请号 FR19700007318 申请日期 1970.03.02
申请人 DELALANDE 发明人
分类号 (IPC1-7):61K27/00;07C123/00 主分类号 (IPC1-7):61K27/00
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