| 摘要 |
A continuous fermenter vessel (1) such as an air-lift fermenter for receiving a suspension culture of cells, the vessel comprising; means (17) for agitating a suspension culture received in a first portion of the vessel (11, 13); a second portion of the vessel (19) defining, in use, a static settling zone, at least part of the bottom of the second portion (21) communicating with the first portion; an inlet means (25) for the continuous supply of culture medium to the vessel; and an outlet (23) for the continuous withdrawal of culture supernatant from the second portion of the vessel from a point spaced above the bottom of the second portion wherein, in use, cells settling in the second portion are returned to the agitated suspension culture, and culture supernatant having a lower concentration of cells than the suspension culture is withdrawn from the second portion. |
