发明名称 PROCEDIMIENTO PARA LA OBTENCION DE CLORHIDRATO DE 2-(3,4-DI-METOXIFENIL)-(-N-2(3,4-DIMETOXIFENIL)ETIL)-N-METIL-1,3-DI- TIAN-2-PROPILAMINO-1,1,3,3-TETROXIDO
摘要 <p>2- (3,4-Di-methoxyphenyl) N-2(3,4-dimethoxy phenyl) ethyl N-methyl 1,3-dithiane 2-propylamino 1,1,3,3-tetroxide hydrochloride of formula (I), for treatment of certain cardiopathic complaints, is made by (a) reaction of 2-(3,4-dimethoxy phenyl) m-dithiene 1,1,3,3-tetroxide with molten sodium in an inert organic solvent with b.pt. below 100 deg.C under 3-6 kg/cm. pressure at 100-105 deg.C; and (b) reaction of the prod. with N-(3-chloro propyl) 3,4-dimethoxy N-methyl phenetylamine at 60-100 deg.C under atmos pressure.</p>
申请公布号 ES550860(D0) 申请公布日期 1987.03.01
申请号 ES19600005508 申请日期 1986.01.14
申请人 SEPTA,S.A. 发明人
分类号 A61K31/385;C07D339/08;(IPC1-7):C07D339/08 主分类号 A61K31/385
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