发明名称 |
MONOCLONAL ANTIBODIES FOR HUMAN NON-SMALL CELL LUNG CARCINOMAS |
摘要 |
The present invention is concerned with two novel monoclonal antibodies which define carbohydrate antigens associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in the lung of a subject. The method involves examining tissue from the subject for the presence of antigens which are Lex or Ley antigen or which have the characteristics of Ley and Lex.
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申请公布号 |
CA1337755(C) |
申请公布日期 |
1995.12.19 |
申请号 |
CA19860508176 |
申请日期 |
1986.05.01 |
申请人 |
ONCOGEN |
发明人 |
HELLSTROM, INGEGERD;BROWN, JOSEPH P.;HELLSTROM, KARL ERIK;HORN, DIANE;LINSLEY, PETER |
分类号 |
G01N33/574;A61K39/395;C07K14/005;C07K14/195;C07K14/705;C07K16/00;C07K16/30;C07K19/00;C12N5/00;C12N5/10;C12N15/00;C12N15/02;C12P21/00;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C12N5/18 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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