| 摘要 |
NEW MATERIAL:The compound of formula I[m is 0-3; n is 0 or 1; R<1> is H, alkoxy or CF3; R<2> is -NHR<4> or group of formula II or III(R<4> is phenyl or group of formula III; R<5> is H, alkyl, phenyl, pyridyl, etc.; p is 0 or 1; q is 0-3); R<3> is saturated heterocyclic group containing N and/or O or -NR<6>R<7>(R<6> and R<7> are H, alkyl, hydroxyaralkyl, etc.)] or its acid addition salt. EXAMPLE:1-(3-Morpholinopropyl)-2-{4-(2-guanidinothiazol-4-yl)phenyl}-a minoben zimidazole. USE:An antiulcer agent having reduced side effects (e.g. antiandrogen effect, insanity-inducing effect, etc.). PREPARATION:For example, the compound of formula I wherein R<2> and NHR<4> can be produced by reacting the phenylenediamine compound of formula IV with the thioisocyanate compound of formula SCN-R<4>, and reacting the resultant compound of formula V with a thioamide-activating reagent (e.g. mercury oxide). |
