GENE ENCODING beta -GALACTOSIDE alpha -2,6-SIALYLTRANSFERASE

摘要

A novel gene encoding a protein having the beta -galactoside alpha -2,6-sialyltransferase activity. This gene has the amino acid sequence represented by SEQ ID NO:1 optionally undergoing the deletion, substitution or addition of one or more amino acids and encodes the protein with the beta -galactoside alpha -2,6-sialyltransferase activity. The invention further provides expression vectors for the beta -galactoside alpha -2,6-sialyltransferase protein with the use of the above gene and host cells and recombinant proteins thereof. The amino acid sequence of the enzyme encoded by the above gene is not homologous with that of the conventionally known sialyltransferases. Moreover, the membrane-binding region thereof is located at the C-end differing from those of the conventionally known enzymes.