OCTAHYDROBENZO(6,7)CYCLOHEPT(1,2-B)-1,4-OXAZINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATION CONTAINING THEM

摘要

4-Substituted-2,3,4,4a,5,6,7,11b-octahydrobenzo[6,7]cyclohept[1,2-b]-1 ,4-oxazines are prepared from the corresponding 6-(substituted amino)-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-ol. The trans-4-substituted-2,3,4,4a,5,6,7,11b-octahydrobenzo[6,7]cyclohept[1, 2-b]-1,4-oxazines have alpha -adrenergic agonist and tetrabenazine antagonist activity.