Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient.

摘要

Described are novel compounds of the formula (IV) wherein R1 is a hydrogen atom, a hydroxyl group or a protected hydroxyl group and R2 is a hydrogen atom or a protecting group, a pharmaceutical composition useful as a cell differentiation-inducing agent, which contains an effective amount of a compound of the formula IV (wherein R2 is H) as an active ingredient and a pharmaceutically acceptable carrier or diluent, a method of inducing cell differentiation by administering an effective amount of a compound of the formula IV (wherein R2 is H) to a patient, and a process for producing a compound of the formula (IV) by subjecting a previtamin D3 derivative of the formula (III) wherein R1 and R2 are as defined above, to thermal isomerization to yield a vitamin D3 derivative of the formula (IV) mentioned above.