| 摘要 |
<p>6-Substituted androsta-1,4-diene-3,17-dione derivatives of formula (I) …<CHEM>… wherein… R is (1) the group-N3;… (2) a group …<CHEM>… wherein each of r1 and R2 is, independently, hydrogen or unsaturated C1-C22 alkyl;… (3) a group -NHCOR3 wherein R3 is… (a) hydrogen;… (b) C1-C3 alkoxy or carboxy;… (c) C1-C22 alkyl either unsubstituted or substituted by a carboxy group; or… (d) a group …<CHEM>… wherein R1 and R2 are as defined above; or… (4) a group -NHSO2R4 wherein R4 is unsubstituted C1-C4 alkyl, or phenyl either unsubstituted or substituted by C1-C3 alkyl, halogen or nitro;… and the pharmaceutically acceptable salts thereof are aromatase inhibitors and can be used, e.g. in the treatment of hormone-dependent tumors.</p> |
