| 摘要 |
NEW MATERIAL:An isoquinoline derivative of formula I (A is ethylene unsubstituted or substituted in H atoms bonding to carbon atoms with alkyl of 1-6 carbon atoms, phenyl or benzyl; B is propylene unsubstituted or substituted with 1-6 carbon atoms, phenyl, benzyl; R is H, 1-6C alkyl) and its acid adduct. EXAMPLE:1-(5-Isoquinolinesulfonyl)homopiperazine. USE:It acts on smooth muscles of blood vessels in mammarians and is used as a vasodilator, cerebral circulation improver, remedy for heart attack and as a preventive for cerebral thrombosis and hypertension. PREPARATION:The reaction of 5-isoquinolinesulfonyl chloride of formula VII with a homopiperazine derivative of formula VIII in the presence of an acid acceptor gives the compound of formula I. |
