摘要 |
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof: <CHEM> wherein: R1 and R9 are independently phenyl, phenyl C1-4 alkyl, phenyl C2-4 alkenyl or pyridyl, the aromatic moiety optionally substituted by one, two or three of halogen, trifluoromethyl, C1-4 alkoxy, C1-4 alkyl, cyano, hydroxy, nitro, NR10R11 or O2SNR10R11 wherein R10 and R11 are independently hydrogen or C1-6 alkyl or together are C3-6 polymethylene, or disubstituted at adjacent carbon atoms by C1-2 alkylenedioxy; C3-8 cycloalkyl; or aliphatic heterocyclyl having up to six ring atoms the heteroatom(s) being selected from oxygen, sulphur or nitrogen; m and n are independently integers of 0 to 3, such that m + n is 0 to 3; and R2 and R8 are independently hydrogen C1-4 alkyl or phenyl C1-4 alkyl, R3 is C1-4 alkyl optionally substituted by hydroxy or thiol or phenyl C1-4 alkyl, or together with R4 is C3-6 polymethylene, R4 is hydrogen, C1-4 alkyl, phenyl C1-4 alkyl or as defined with R3, or together with R5 is -(CH2)p-where p is an integer from 2 to 6 such that m + p is 3 to 6, R5 is hydrogen, C1-4 alkyl or as defined with R4, or together with R6 is -(CH2)q-where q is an integer from 2 to 6 such that n + q is 3 to 6, R6 is hydrogen, C1-4 alkyl, phenyl C1-4 alkyl or as defined with R5, or together with R7 is C3-6 polymethylene, and R7 is C1-4 alkyl optionally substituted by hydroxy or thiol, phenyl C1-4 alkyl or as defined with R6, in which any phenyl moiety in R2,R3,R4,R6,R7 and R8 is optionally substituted by one or two of halogen, trifluoromethyl, C1-4 alkoxy or C1-4 alkyl. Such compounds have been found to possess cardiovascular activity, in particular calcium antagonistic activity which indicates that they are of potential use in the treatment of angina. |