摘要 |
1-(4-Fluoro benzyl) 2-((1-(4-methoxy phenethyl)4-piperidinyl) amino) benzimidazole of formula (I) is made by a phase transference reaction of 2-(4-piperidinyl-amino) 1-(4-fluoro benzyl) benzimidazole with 4-methoxy phenethyl chloride in an inert, aprotic, slightly polar organic solvent in presence of an HCl acceptor, e.g. Na or K carbonates, and a phase transfer catalyst e.g. tetrabutyl ammonium bromide.
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