Dihydro and tetrahydroquinoline derivatives.

摘要

This invention relates to novel lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic activities. The present new compounds are di-and tetra-hydroquinoline or di- and tetra-hydronapthalene derivatives, more particularly, 1,2-, 1,4-, 5,6-, or 7,8-dihydro; 1,2,3,4,-tetrahydro-; 5,8-dihydro-; or 5,6,7,8-tetrahydroquinoline or napthalene derivatives of a compound of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="83" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and oxides, quaternary ammonium salts and acid salts thereof; wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>A is CH or N;</ListItem><ListItem>Z is an alkylene chain containing up to 10 carbon atoms in the principal chain and a total of up to 12 carbon atoms and the said alkylene chain may be attached to the phenyl group through an oxygen atom;</ListItem><ListItem>R is the substituent OR<Sub>6</Sub> attached to one of the carbon atoms of Z in which R<Sub>6</Sub> is H, lower alkyl or phenyl;</ListItem><ListItem>X is -0(CHR<Sub>5</Sub>)<Sub>m</Sub>-, alkylene of up to 2 carbon atoms in the principal chain and up to a total of 4 carbon atoms or -</ListItem><ListItem>-C (CHR<Sub>5</Sub>)<Sub>m</Sub>-, wherein R<Sub>5</Sub> is H or CH<Sub>3</Sub>; OH</ListItem><ListItem>R<Sub>1</Sub>, R<Sub>2</Sub>, R<Sub>3</Sub>, and R<Sub>4</Sub>, are each H or OH;</ListItem><ListItem>n' = 1 or 2; and</ListItem><ListItem>m = 1 or 2.</ListItem></UnorderedLists>