发明名称 |
(-)-1B-ETHYL-1A-HYDROXYMETHYL-1,2,3,4,6,7,12,12BA-OCTAHYDROINDOLO(2,3-A) QUINOLIZINE PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
摘要 |
<p>The invention relates to the new (-)-1 beta -ethyl-1 alpha -hydroxymethyl-1,2, 3,4,6,7,12,12b alpha -octa-hydroindolo[2,3-a] quinolizine of the formula (I) <IMAGE> (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.</p> |
申请公布号 |
GR861027(B) |
申请公布日期 |
1986.08.12 |
申请号 |
GR19860101027 |
申请日期 |
1986.04.18 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT |
发明人 |
DR. SZANTAY CSABA;DR. SZABO LAJOS;DR. KALAUS GYORGY;DR. SZOMBATHELYI ZSOLT;DR. KARPATI EGON;KISS BELA;CSOMOR KATALIN;LASZLOVSZKY ISTVAN;LAPIS ERZSEBET;DR. SZPORNY LASZLO;FORGACS LILLA;KUTHI CSABA;GERE ANIKO |
分类号 |
A61K31/435;A61P9/00;A61P9/08;C07D471/14 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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