| 摘要 |
4-Hydroxy 2-methyl N-(2-pyridyl) 2H-thieno (2,3-e) 1,2-thiazine 3- carboxamide 1,1-dioxide of formula (I) is made by (a) reacting the ethyl ester of 4-hydroxy 2-methyl 2H-thieno (2,3-e) 1,2-thiazine 3-carboxylic acid 1,1-dioxide (II) with a 2-amino pyridyl magnesium halide (III) in ether-xylene solvent mixt. at 0-140 deg.C for 1-15 hrs. to give (IV); (b) hydrolysing this in acid or basic medium to obtain (I). X is Cl, Br or I.
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