| 摘要 |
<p>Compounds of structure (I) …<CHEM>… in which, R<1> to R<4> are the same or different and are each hydrogen, C1-6alkyl, halogen, trifluoromethyl, C1-6alkoxy, C1-6alkanoyl, C1-6alkoxycarbonyl, RCF2O, an ethoxy group substituted by 3 to 5 fluorine atoms, or R<2> and R<3> together form a group -O(CR2)mO- where m is 1 or 2, and each group R is hydrogen or fluorine; n is 0 or 1; R<5> and R<6> are the same or different and are each hydrogen, C1-6alkyl or C3-6cycloalkyl, or R<5> and R<6> together with the nitrogen atom to which they are attached form an azetidino, pyrrolidino, piperidino, piperazino, N-C1-4alkylpiperazino or morpholino group; and one of X and Y is a nitrogen atom, and the other is a group CR<7> where R<7> is hydrogen, C1-6alkyl or NH2; processes for their preparation; intermediates used in their preparation; compositions containing them and their use in therapy in the inhibition of gastric acid.</p> |
