Novel pyrrolobenzimidazoles, process for their preparation and medicaments containing these compounds, and novel intermediates

摘要

Novel pyrrolobenzimidazoles of the formula I <IMAGE> in which R1 denotes a hydrogen atom, an alkyl, alkenyl or a cycloalkyl group, R2 denotes a hydrogen atom, an alkyl, alkenyl or cyano group, a carbonyl group substituted by a hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino group, or, together with R1, represents a cycloalkylene group or R1 and R2 together form an alkylidene or cycloalkylidene group, X denotes a valency dash, a C1-C4-alkylene group or the vinyl group, T equals oxygen or denotes sulphur, Py represents a 2- ,3- or 4-pyridyl radical, which optionally carries an oxygen atom on the ring hetero atom and/or can be substituted by one or more alkyl, alkoxy, hydroxyl, cyano or nitro groups, as well as by halogen, their tautomers and their physiologically tolerable salts, process for their preparation, medicaments, which contain compounds of the formula I, for the treatment of cardiac and circulatory disorders, and compounds of the formula IIa <IMAGE> in which R1 and R2 have the meanings given in formula I, A and B denote hydrogen, an amino or nitro group or the group <IMAGE> with the proviso that A and B are different, but can simultaneously represent two amino groups, as intermediates for the preparation of compounds of the formula I.