7-AMINO-3-SUBSTITUTED-METHYL-3-CEPHEM-4-CARBOXYLIC ACID AND LOWER ALKYLSILYL DERIVATIVES THEREOF, AND THEIR PRODUCTION

摘要

Various 7-amino-3-substituted-methyl-3-cephem-4-carboxylic acids and lower alkylsilyl derivatives such as 7-amino-3-(2,3-cyclopenteno-1-pyridiniomethyl)-3-cephem-4-carboxylic acid iodide and trimethylsilyl 7-trimethyl-silylamino-3-(5,6,7,8-tetrahydro-2-isoquinoliniomethyl)-3- cephem-4-carboxylate iodide are valuable intermediates in the preparation of new and novel antibacterial agents. A new process for the preparation of these acids and the derivatives has been devised.