| 摘要 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof: <IMAGE> (I) wherein: X is NR wherein R is hydrogen or C1-6 alkyl, oxygen, sulphur, SO or SO2; R1 is COR5 wherein R5 is hydroxy, or COR5 is a pharmaceutically acceptable ester or amide group; or CF3; and R2 is hydrogen, C1-6 alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; or R2 is COR5 as defined or CF3 and R1 is hydrogen; R3 is C1-10 alkyl, optionally substituted by hydroxy, C1-4 alkoxy, thiol, C1-4 alkylthio or NR6R7 wherein R6 and R7 are independently hydrogen or C1-6 alkyl or together are C3-6 polymethylene; C2-10 alkenyl or phenyl optionally substituted by one or two of halogen, CF3, C1-4 alkoxy, C1-4 alkyl, hydroxy, nitro, cyano, C2-10 acyloxy, NR8R9 wherein R8 and R9 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl or COR10 wherein R10 is hydroxy, C1-6 alkoxy or NR11R12 wherein R11 and R12 are independently selected from hydrogen or C1-6 alkyl; and R4 is hydrogen; or C1-4 alkyl or benzyl attached at nitrogen atom 1 or 2 having anti-inflammatory and/or anti-allergy activity, a process for their preparation and their use as pharmaceuticals. |
