| 摘要 |
<p>Cpds. of formula (I), their optical isomers and acid addn. salts are new. (n= 1-6; R1= H or 1-4C alkyl and R2= H; or CR1R2= CO; R3= H, 1-6C alkyl, phenyl, benzyl, hydroxy lower alkyl and its acylates, carbamoyl alkyl, carboxyalkyl, alkoxycarbonylalkyl or aminoacid side chains; R4= H, 1-6C alkyl, benzyl or hydroxy lower alkyl; Y= H, 1-4C alkyl, halo or lower alkoxy; A= an amide forming gp. in which the N substits. are (i) H; (ii) 1-6C alkyl; (iii) 1-6C hydroxyalkyl and its 1-6C aliphatic acylates or 7-12C aryl acylates; (iv) 3-8C cycloalkyl or 4-12C cycloalkyl (lower)alkyl opt. ring substd. by lower alkyl, lower alkoxy, OH, OCOR5, halo, NH2, N(R5)2, NHCOR5, COOH or COOR5; (v) phenyl or phenyl(lower)alkyl in which thephenyl ring is opt. substd. by one or more lower alkyl, halo or lower alkoxy gps.; or an NH2, N(R5)2, NHCOR5, COOH or COOR5 gp.; or (vi) morpholinyl, piperidinyl, perhexylenyl, N-loweralkylpiperazinyl, pyrrolidinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, (+-)-decahydroquinolinyl or indolinyl; and R5= lower alkyl).</p> |
