| 摘要 |
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X-R1-(W)D-Phe-R3-R4-R5-R6(V)-R7-Arg-Pro-R10 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R1 is dehydro-Pro, Pro, D-pGlu, D-Phe, D-Trp or beta -D-NAL; W is F, Cl, Cl2 Br, NO2 or C alpha Me-Cl; R3 is D-Trp, (NinFor)D-Trp or D-Trp which is substituted in the 5- or 6-position with NO2, NH2, OCH3, F, Cl, Br or CH3; R4 is Ser, Orn, AAL or aBu; R5 is Tyr, (3F)Phe, (2F)Phe, (3I)Tyr, (3CH3)Phe, (2CH3)Phe, (3Cl)Phe or (2Cl)Phe; R6 is D-Lys, D-Orn or D-Dap; V is (arg-R',R'')n(X), with n being 1 to 5 and R' and R'' being H, methyl, ethyl, propyl or butyl; R7 is Leu, NML, Nle or Nva; and R10 is Gly-NH2, D-Ala-NH2 or NH-Y, with Y being lower alkyl, cycloalkyl, fluoro lower alkyl or <IMAGE> where Q is H or lower alkyl. |
