| 摘要 |
Piperazine derivs. of formula (I) and their enantiomers and diastereoisomers are new (where R is opt. substd. aryl, aralkyl, or a heterocyclic gp.; R1 is H or 1-4C alkyl; A is an opt. branched, opt. unsatd. aliphatic hydrocarbon chain; R2 and R3 are H, opt. unsatd. (cyclo)alkyl or opt. substd. aryl, or R2 and R3 may be linked via a CH2, N O, or S gp. to form a ring; R4 is H or alkyl; X is halogen or an anion of an (in)organic acid; n is 0-3 or is 0.5, 1.5 or 2.5 in the case of bifunctional acids). - (I) are (a) anticholinergic agents which inhibit gastric secretion have a spasmolytic effect on the gastrointestinal tract, bladder, kidneys, etc., and have mydriatic, anti-parkinsonian and anti-kinetose (sic) activity, or GBAB- GB2135991 B Piperazine derivs. of formula (I) and their enantiomers and diasteroisomers are new (where R is opt. substd. aryl, aralkyl, or a heterocyclic gp.; R1 is H or 1-4C alkyl,; A is an opt. branched, opt. unsatd. aliphatic hydrocarbon chain; R2 and R3 are H, opt. unsatd. (cyclo)alkyl or opt. substd. aryl, or R2 and R3 may be linked via a CH2, N, O or S gp. to form a ring; R4 is H or alkyl; X is halogen or an anion of an (in)organic acid; n is 0-3 or is 0.5, 1.5 or 2.5 in the case of bifunctional acids). - (I) are (a) anticholinergic agents which inhibit gastric secretion have a spasmolytic effect on the gastrointestinal tract, bladder, kidneys, etc. and have mydriatic, anti-parkinsonian and antikinetose (sic) activity, or (b) antihistamine agents. USAB- US4457931 A Piperazine derivs. of formula (I), their enantiomers and quat. salts are new. In (I), R is opt. mono- or di-CF3-substd. Ph; or R is CH2Ph or 2-pyridyl; A is 1-4C alkylene; and Q and Q' are each H, 2-6 C alkyl or opt. substd. aryl; or Q is H and Q' is cyclohexyl; or NQQ' is a 5-7 membered, saturated heterocyclic ring, opt. contg. an additional N, O or S heteroatom, or denotes an adamantyl ring structure.
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