| 摘要 |
1-(alkoxy or aroxy)carbonyloxyalkyl esters of structural formula (I): <CHEM> wherein: R is (a) lower alkyl; (b) lower cycloalkyl; (c) unsubstituted or substituted aryl; or (d) aralkyl; R<1> is (a) hydrogen; (b) lower alkyl; (c) lower cycloalkyl; or (d) aryl; R<2> is (a) hydrogen; (b) lower alkanoyl; (c) lower alkoxycarbonyl; R<3> is (a) hydrogen; or (b) lower alkyl; and X is halo are disclosed. Those compounds are stable in aqueous medium and non-irritant to mucous embranes of mouth, throat, and stomach. Accordingly, they are useful Prodrugs of the analgesic and anti-inflammatory drug diflunisal. |
