| 摘要 |
Medicaments containing, as active ingredient, a substituted piperidine of formula (I) or its salt with a pharmaceutically acceptable acid, are new. X=CO, (x) or (xi), Ar=(A), (B), (C) or (D). R=H or 1-4C alkyl, Y and Z=H or 1-3C alkoxy. - Compounds of formula (I) where X is CHOH or CHNH2, and compounds of formula (I) where X is CO and Ar is (A) or (D), are claimed per se. LD50 is greater than 15 mg/kg i.v. (mouse). The compounds may be given orally or by injection. The oral daily dose is 50-800 mg, the unit dosage being 10-100 mg.
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