| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R<1> is H; R<2> is H, lower alkyl, ar(lower)alkyl, lower alkenyl, or aryl; R<3> is obtained by eliminating H from R<2>, or R<2> and R<3> are linked to form (aryl-substituted) 2-6C alkylidene, etc.; R<4> is di(lower)alkylamino, (heterocyclic group-substituted)lower alkyl, or (substituted)heterocyclic group; R<5> is H, or lower alkyl; X is O, or S] and its salt. EXAMPLE:N[(4-Pyridylcarbamoyl)amino]-1,2,3,6-tetrahydropyridine. USE:An anti-inflammatory drug or an analgesic. Useful for remedying inflammations and pains such as headache, toothache, menstrual pain, etc. PREPARATION:For example, a compound shown by the formula II or its salt is reacted with a compound shown by the formula III or its salt in an organic solvent suchas methylene chloride, etc. in the presence of a base such as triethyleneamine, etc. under cooling - under heating, to give a compound shown by the formula I where R<5> is H. |
