Pyrrolizidine compounds, methods for their production, and their uses.

摘要

A novel pyrrolizidine compound of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="29" wi="56" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>(wherein R<Sup>1</Sup> is an alkyl group of 1 to 4 carbon atoms or a phenyl group; and R<Sup>2</Sup> and R<Sup>3</Sup> are such that at least one of them is an alkyl group of 1 to 4 carbon atoms with the other, if any, being a hydrogen atom) is produced by reacting Δ<Sup>4(8)</Sup>-dehydropyrrolizidine with a substituted malonic acid and thus formed 2-substituted-8-pyrrolizidineacetic acid with a substituted aniline. The product is optionally subjected to optical resolution. The pyrrolizidine compound has more potent antiarrhythmic activity than known similar pyrrolizidine compounds.