| 摘要 |
<p>57 2-Benzyl-4-(A-pyridyl)thiazoles and derivatives thereof of formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="40" wi="85" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>thereof are disclosed wherein dently are, e.g., hydrogen; halo; R<Sub>a</Sub>R<Sub>b</Sub> wherein R, and C<Sub>1-6</Sub> alkyl single or a double bond: for double bond-connection, R<Sup>2</Sup> can be, e.g., =0 or =S; for single-bond connection, there can be one or two sets of R<Sup>2</Sup> and each R<Sup>2</Sup> independently is R; R<Sup>3</Sup> is R<Sub>a</Sub>, halo or haloloweralkyl; n is 1 to 4; m is 1 to 5; and q is 0 or 1. These compounds have been made from converting a benzyl cyanide to the corresponding thioamide followed by condensation with a 4-bromoacetylpyridine. The thiazole derivatives are found to be effective immunoregulants.</p> |
