摘要 |
<p>PROCESS FOR MAKING 1-(3-BENZYLOXYPHENYL)-1,1-DIMETHYLHEPTANE AND INTERMEDIATES THEREFOR Process for making 1-(3-benzyloxyphenyl)-1,1-di-methylheptane, a valuable intermediate for the preparation of analgesic agents, which comprises benzylation of 3-hydroxyacetophenone to produce 3-benzyloxyaceto-phenone which is converted to 1-(3-benzyloxyphenyl)-1-methylheptan-1-ol via Grignard reaction with n-hexyl-magnesium bromide; chlorination of said heptanol by reaction with hydrogen chloride followed by methylation of the thus-produced 1-(3-benzyloxyphenyl)-1-chloro-1-methylheptane with trimethylaluminum.</p> |