| 摘要 |
PURPOSE:To obtain a Grignard salt of lactam useful as a basic catalyst and a reagent for various reactions by one reaction operation safely, by reacting a metal Mg with an alkyl halide or an aryl halide and a lactam. CONSTITUTION:A lactam shown by the formula I (R is 3-11C aliphatic hydrocarbon residue) is reacted with metal Mg and an alkyl halide or an aryl halide at -15-120 deg.C, to give a compound shown by the formula II (n is 3-11; Y is Cl, Br, or I). Metal Mg having a small amount of oxidized film on the surface and >=90% purity is preferable as the metal Mg, and it is preferably in the form such as flake, powder, etc. having large specific surface area. A monohalogenated hydrocarbon is preferably used as the halogenated hydrocarbon, and its amount used is 1.0-1.5mol based on 1mol metal Mg. An amount of the lactam used is 0.9-5mol based on 1mol metal Mg. The reaction is carried out in a solvent such as THF, etc.
|
