| 摘要 |
A process for preparing 7-halo-7-deoxylincomycin or an analogue thereof, which comprises… (a) reacting a starting compound selected from lincomycin and analogues thereof, with an amide halide having the formula …<CHEM>… wherein each Hal is bromine or chlorine, and either R1 and R2 are independently selected from aryl and C1-8 alkyl or NR1R2 is morpholino or a heterocyclic ring containing 4 to 8 ring atoms selected from carbon and nitrogen, to form an adduct;… (b) heating the adduct, to form a 7-halo-7-deoxy adduct; and… (c) hydrolysing the 7-halo-7-deoxy adduct with an aqueous base. |
