| 摘要 |
7-Oxabicycloheptane substituted prostaglandin alcohols are provided having the structural formula <IMAGE> wherein A is -CH=CH-(CH2)n- or (CH2)q; B is a single bond or -CH=CH-; n is 1 to 5; q is 1 to 6; Q is -CH=CH- or (CH2)2; and R is lower alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl or lower alkenyl, with the proviso that when B is -CH=CH-, n is 1 to 3 or q is 1 to 4 and when B is a single bond, n is 1 to 5 or q is 1 to 6, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease. |
