发明名称 3(2H)-pyridazinone derivatives, a process and intermediates for preparing them and medicaments containing them and/or other 3(2H)-pyridazinone derivatives.
摘要 The subject-matter of the invention are 3(2H)-Pyridazinone derivatives of the general formula <CHEM> wherein R stands for an ethyl or propyl group substituted by a terminal halogen atom or hydroxyl group or a terminal group of the formula <CHEM> in which latter R1 represents a hydrogen atom or an optionally substituted benzyl group and R2 represents a hydrogen atom or an optionally substituted benzoÄ1,4Üdioxan-2-yl-methyl or benzoÄ1,4Üdioxan-2-yl-ethyl group or a group of the formula <CHEM> in which latter n is 2 or 3 and R3 stands for an optionally substituted phenoxy or phenylthio group and X stands for a hydrogen or halogen atom or an optionally substituted saturated or unsaturated 5- or 6-membered heterocyclic group. Furthermore the subject-matter of the invention are a process and intermediates for preparing these compounds and medicaments containing them and/or other 3(2H)-pyridazinone derivatives. The compounds according to the invention inhibit the adrenergic alpha1 receptors, have a calcium-antagonistic effect and exert blood pressure lowering action.
申请公布号 EP0220735(A2) 申请公布日期 1987.05.06
申请号 EP19860115076 申请日期 1986.10.30
申请人 RICHTER GEDEON VEGYESZETI GYAR R.T. 发明人 KASZTREINER, ENDRE, DR.;RABLOCZKY, GYORGY, DR.;MAKK, NANDOR, DR.;JASZLITS, LASZLO, DR.;MATYUS, PETER, DR.;CSEH, GYORGY, DR.;PRIBUSZ, GEB. RAPP, ILDIKO;CZAKO, KLARA;DIESLER, ESZTER;ELEKES, ISTVAN, DR.;KAUFER, LASZLO;KUHAR, GEB. KURTHY, MARIA;KINCSESSY, JUDIT;KOSARY, JUDIT DR.,;NAGY, GYONGYI GEB. CSOKAS,
分类号 C07D237/00;A61K31/50;A61K31/535;A61P9/12;C07D237/08;C07D237/12;C07D237/14;C07D237/20;C07D237/22;C07D319/00;C07D403/04;C07D405/12;C07D521/00 主分类号 C07D237/00
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