| 摘要 |
<p>NEW MATERIAL:7-Deazapurine derivative of formula I [R<1> is phenyl which bears at least one substituent selected from OR<3>, SR<4>, NR<5>R<6> (R<3>-R<6> are H, alkyl, phenyl anr R<5> and R<6> may form a ring together with N; R<2> is amino] or its salt. EXAMPLE:2-Amino-5-( 2-methoxyphenylaminomethyl )pyrrolo[ 2,3-d ]pyrimidine-4- one. USE:Antitumor agent. PREPARATION:For example, the reaction between a compound of formula II(R<7>, R<8> are alkyl having methylene in its alpha-position, alkenyl, aralkyl; R<7> and R<8> may form cyclic amino together with N) or its salt and an amine of the formula: H2N-R<1> or its salt gives a compound of formula I.</p> |
