| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R1 is H, or NO2; R2 is COOH, COOR (R is alcohol residue), -CONH2, or -CH2OH]. EXAMPLE:N-gamma-L-Glutanylkyotorphin. USE:An intermediate for an analgesic, or a drug. Showing effect even by peripheral administration such as intravenous injection, etc. PREPARATION:0.01-0.2M gamma-glutamyltyrosine shown by the formula II (R3 is OH, or OR) or its derivative is reacted with 0.1-2M arginine shown by the formula III or its derivative in the presence of protease preferably in an aqueous medium at 9-11pH at 30-40 deg.C. |
