| 摘要 |
NEW MATERIAL:A compound shown by the formula I (C of * is asymmetric carbon having absolute configuration of R or S). EXAMPLE:(R)-(+)-1-Ethyl-6-difluoro-1,4-dihydro-7-( 3-methyl-1-piperazinyl )-4-oxoquinoline-3-carboxylic acid. USE:An antibacterial agent. Having wide antibacterial action on Gram-positive and Gram-negative bacteria. PREPARATION:A 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivative shown by the formula II is reacted with an optically active piperazine derivative shown by the formula III in the absence of a solvent or in a solvent such as an alcohol at room temperature -200 deg.C, preferalby at 100-180 deg.C, to give a compound shown by the formula I . |
