| 摘要 |
NEW MATERIAL:A pyrrolidine devirative of formula I (X is halogen; R<1>, R<2> are H, alkyl; R<3> is henyl which may be substituted with alkyl). USE:It is used as an intermediate of alkaloid medicine and agricultural chemicals. PREPARATION:An amide of formula II is allowed to react with a hologenating agent such as bromine, iodine, N-bromosuccinimide, N-iodosuccinimide in a solvent such as dimethoxyethane, ether, acetonitrile, methylene chloride at room temperaure -80 deg.C for 5min-5hr to give the compound of formula I . The compound of formula II is obtained by reaction of an amine of formula III with a sulfonyl chloride of formula IV in the presence of a base such as pyridine or alpha-picoline according to a usual method.
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