摘要 |
NEW MATERIAL:A compound expressed by formula I [R is (substituted) cyclic amino except 3-substituted-1-piperazinyl; X<1> and X<2> are halogen]. EXAMPLE:1-Cyclopropyl-6, 8-difluoro-7-( 1-piperazinyl )-1, 4-dihydro-4-oxoquinoline- 3-carboxylic acid. USE:A medicine, veterinary and fish drug, food preservative, germicide for external use and disinfectant. PREPARATION:For example, ethyl cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate expressed by formula II is reacted with a cyclic amine expressed by the formula RH in a solvent, e.g. dimethyl sulfoxide, at 50-150 deg.C for 1-3hr to form a 7-amino substitution product expressed by formula IIIwhich is directly as a crude product hydrolyzed or isolated and hydrolyzed with an acid or alkali to afford the aimed compound expressed by formula I .
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