发明名称 Substituted tyrosil alanine dipeptide amides.
摘要 <p>Dipeptides of formula (I) and acid addn salts are new. (where R1 = 1-4C alkyl, R2 =H, OH, OCO2R1 or 1-4C alkyl; R3 = H or 1-6C alkyl, R4,R5 = H or 1-6C alkyl, n = 1-6, X=H, OH, OCO2R1, A= cyclohexyl or phenyl opt. substd. with 1 or more 1-6C alkyl, one or more NH2, OH, halogen, NO2 or 1-6C alkoxy, v represents the asymmetric C that may be racemic or have the D or L config. w represents the asymmetric C when R4 and R5 are not the same that may be racemic or have the D or L config.). Several cpds. (I) are claimed e.g. 2,6-dimethyltyrosyl N-(3-phenylpropyl)-D- alancinaminde hydrochloride (Ia) and 2,6-dimethyltyrosyl- N-(3-phenyl-propyl) is ovalinamide monohydrochloride. -</p>
申请公布号 EP0154234(A2) 申请公布日期 1985.09.11
申请号 EP19850101690 申请日期 1985.02.15
申请人 G.D. SEARLE & CO. 发明人 HANSEN, DONALD WILLIS;MAZUR, ROBERT HENRY;PILIPAUSKAS, DANIEL RICHARD
分类号 A61K38/00;C07K5/065;(IPC1-7):C07K5/06;A61K37/02 主分类号 A61K38/00
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