PHOSPHORUS-CONTAINING OLIGOPEPTIDES, PROCESSES FOR PREPARATION THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

Oligopeptides that contain phosporus, represented by the formula in which R1 represents hydrogen, lower alkyl, substituted or non substituted phenyl alkyl, or R4CO- (where R4 represents hydrogen, lower alkyl, or substituted or non substituted phenyl alkyl), R2 represents lower alkyl, R3 represents hydrogen, lower alkyl, or substituted or non substituted phenyl alkyl, and Y represents hydrogen or hydroxyl exhibiting a hypertensive activity. These oligopeptides can be prepared either by synthetic methods or, for two of them (namely antibiotics K-4 and K26), by cultivating microorganisms belonging to the genus ACTINOMADURA SPICULOSOSPORA NOV. SP K-4 (Ferm P-6101) and ACTINOMYCES K-26 (FERM P-5889, NRRL 12379) respectively.