| 摘要 |
<p>NEW MATERIAL:A compound of formula I [Y is (protected) amino, carboxyl; R1 is 1-6C alkyl, formula II (R3, R4 are H, 1-4C alkyl); R2 is H, protecting group; X is H, halogen, 1-4C alkyl, methylene having 1-4C alkoxy group, substituted nitrogen, methylene substituted with a hetercycle containing 1-4 hetero atoms selected from S and O, formula III (Het is 1-4C alkyl, amino, 5-membered ring containing 1-4 heteroatoms selected from N, S and O)]. EXAMPLE:{ 7-[ 4-( 2-Amino-2-carboxyethyl )-2-imidazolyl ]methoxyiminoaceto }amide-3-acetoxymethyl-3-cephem-4-carboxylic acid. USE:An antibacterial which can be orally administered. PREPARATION:For example, the compound is synthesized according to the process flow shown in the reaction equations (tBu represents tertiary butyl; Boc, tertiary-butoxycarbonyl; Me, methyl; TEA, triethylamine and TFA, trifluoracetic acid).</p> |
