发明名称 |
Derivatives of aminopyridinecarboxylic acids and pharmaceutical compositions containing them |
摘要 |
Derivatives of aminopyridinecarboxylic acids which inhibit the dipeptidyl carboxy peptidase (DPCP), methods for their preparation and pharmaceutical compositions containing them. The compounds have formula: <IMAGE> (I) where Z is hydrogen, alkyl having from 1 to 3 carbon atoms, halogen or alkoxy having from 1 to 3 carbon atoms; R1 is hydrogen, alkyl having from 1 to 6 carbon atoms, arylalkyl having from 7 to 12 carbon atoms, aryl having from 6 to 15 carbon atoms; m and n are an integer of from 0 to 4 each provided, however, the m+n is lower than 5; R2 is hydrogen, alkyl having from 1 to 6 carbon atoms or arylalkyl having from 7 to 12 carbon atoms; R3 is hydrogen or acyl having from 1 to 8 carbon atoms; R4 is hydrogen or alkyl having from 1 to 3 carbon atoms; and their pharmaceutically acceptable salts with organic or inorganic acids.
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申请公布号 |
US4528296(A) |
申请公布日期 |
1985.07.09 |
申请号 |
US19830557584 |
申请日期 |
1983.12.02 |
申请人 |
SIMES, SOCIETA ITALIANA MEDICINALLE SINTETICI |
发明人 |
VECCHIETTI, VITTORIO;FERRARI, GIORGIO;CASAGRANDE, CESARE |
分类号 |
C07D213/79;(IPC1-7):C07D213/80;C07D213/75;A61K31/455 |
主分类号 |
C07D213/79 |
代理机构 |
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主权项 |
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地址 |
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