1-propargyloxy-2-hydroxy-3-piperazino propane esters - having hypotensive and peripheral vasodilating properties

摘要

Title cpds. have formula (I) (where Ar = 3,4,5-trimethoxyphenyl or 3,4,5-trimethoxy phenyl vinyl; R = pyrrolidono-, morpholino-, hexamethylene imino-, or isopropylamino-carbonyl methyl). They are prepd. by the action of 1-propargyloxy-2,3-epoxy-propane on a 1-R-substd. piperazine, followed by treatment with an acid chloride Ar-CO-Cl.