SYNTHESIS OF PHOSPHONOMETHYLATED AMINO ACIDS

摘要

Phosphonomethylated amino acids can be prepared by reacting a dihalide of halomethylphosphonic acid with water to form a halomethylphosphonic acid followed by its reaction with the desired amino acid. Preferably, the process includes as an initial step the reaction of a phosphorus trihalide and formaldehyde to form the dihalide of halomethylphosphonic acid.