WERKWIJZE TER BEREIDING VAN EEN GENEESMIDDEL MET CHOLERETISCHE WERKING ONDER TOEPASSING VAN EEN TERPEEN.

摘要

Title cpds. are prepd. from sobrerol by (a) hydrogenated to form pinol (II) which can be either treated with a peracid to an epoxy pinol and hydrolysed to the 2,6-dihydroxycineol (I) prod. or (II) can be brominated and the obtd. 2,6-di-bromopineole (III) treated with sodium acetate to form the 2,6-diacetoxycineole and then with sulphuric acid to form (I). Medicaments contain (I), (II) or (III) in unit doses contg. 100-200mg. active ingredient. The reaction gives a high yield of prods. in a pure form.