| 摘要 |
<p>NEW MATERIAL:3'Deoxyneplanocin A shown by the formula I . USE:A carcinostatic agent. Having multiplication-inhibitory action on L-5178Y cell. PREPARATION:N<6>, 6'-Di-protecting-neplanocin A shown by the formula II(R1 is protecting group selected from a group consisting of lower alkanoyl and benzoyl which may contain substituent group) is subjected to 2', 3'-O-cyclic thiocarbonylation to give a compound shown by the formula III, which is desulfurized and carbonylated to give an N<6>, 6'-di-protecting-3'-deoxyneplanocin A shown by the formula IV. This compound is then treated with methanol ammonia, so that the protecting groups at N<6>, 6'-positions are deprotected, to give a compound shown by the formula I .</p> |
