| 摘要 |
<p>A 4,4 min -alkylenebis[piperidine-1-(N-amidino-amidine)] derivative of the formula:-
<CHEM>
or a tautomeric form thereof, wherein each of R<1>, R<2>, R<3> and R<4>, which may be the same or different, is hydrogen or an alkyl, alkenyl or alkoxyalkyl radical of up to 20 carbon atoms; or R<1>, R<2> and the nitrogen atom to which they are attached, or R<3> and R<4> and the nitrogen atom to which they are attached, which may be the same or different, are each a 1-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical each of which may bear 1-3C alkyl substituents; a 3-20C cycloalkyl radical; or an optionally substituted phenyl or phenylalkyl radical; provided that at least one of R<1>, R<2>, R<3> and R<4> is other than hydrogen; X is a direct bond or a 1-6C straight- or branched-chain alkyiene radical which is linked to the 3- or 4-positions of the piperidine rings; and R<5> and R<6>, which may be the same or different, are each hydrogen or a 1-8C alkyl radical; and the acid addition salts thereof, processes for their manufacture, and antibacterial and antifungal compositions and methods using said compounds. </p> |
