PROCEDE POUR PREPARER 2,4-DIAMINO-5-(3',4',5'-TRIMETHOXYBENZYLE)PYRIMIDINE

摘要

2,4-Diamino-5-/3',4',5'-trimethoxybenzyl/pyrimidine is prepared by reacting alpha-/3,4,5-trimethoxy-benzal/-beta-methoxypropionitrile with a diethylene glycol monalkyl ether of the formula HO-CH2-CH2-O-CH2-CH2-OR (wherein R is an alkyl group having 1 to 4 carbon atoms) at 60 to 90 DEG C in the presence of an alkali metal alkoxide, and reacting the obtained benzyl isomer of the formula (optionally without separation) with guanidine in the presence of an alkanol having 4 to 8 carbon atoms.