PROCESS FOR PREPARING POLYPEPTIDE DERIVATIVES

摘要

2360.200/DA1 ToN/VMN 82-06-21 Process for Preparing Insulin Derivatives The yield of threonineB30 derivatives of human insulin when amidating des(AlaB30)-insulin with a L-threonine derivative in a mixture of water and a water miscible organic solvent in the presence of trypsin is increased substantially when the content of water in the reaction mixture is between 30 and 10%. B13