摘要 |
The new pharmaceutical form, known as BICAP, permits optimal bioavailability, that is it permits maximum absorption of the drug in the gastrointestinal tract. This produces an optimal concentration in the blood, which enables the duration of treatment to be reduced and at the same time produces rapid improvement in the clinical signs. This reduces the side effects normally associated with treatment based on antibiotics of the traditional form, which are due to the prolongation of the treatment. The tolerability of drugs presented in the BICAP form is thus markedly improved. The preparation process for the new forms consists essentially in the following stages: a) preparation of a nucleus b) preparation of the coating c) preparation of the dry-coated tablet by compression of the coating onto the precompressed nucleus characterised, unlike processes of the known art, in that none of the active constituents or excipients goes through a liquid or wet stage or is formed into a paste or placed in an oven. The pharmeceutical forms obtained in this way are extremely stable. This process is used particularly for the coating of antibiotic (tetracyclines) and multivitamin preparations.
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