| 摘要 |
A pharmaceutical formulation for systemic use in treating acne vulgaris comprising at least one anti-androgen and at least one antibiotic, wherein when the formulation is in unit dosage form the anti-androgen (with progesterone-like properties e.g. cyproterone acetate) is present in an amount of at least 10 mg daily given over 10 days or 100 mg or more in total given during a complete cycle over 21-28 days e.g. about 3,5 mg to 5.0 mg daily or as a single or divided dose. A calendar pack containing pharmaceutical formulation doses for use in treating female acne vulgaris comprising spaced locations corresponding to the days of a menstrual cycle, dosage forms in a first series of said locations providing at the or each location of the series a daily dose of an anti-androgen and a dose of an antibiotic in pharmaceutically administerable form, and dosage forms at a further series of locations following the first series providing a daily dose of antibiotic in pharmaceutically-administerable form without anti-androgen, wherein the dose of anti-androgen is such that at least 100 mg is provided per cycle. A topical pharmaceutical formulation for use comprising a combination of at least one anti-androgen and at least one antibiotic, together with at least one of the conventional pharmaceutically-acceptable carriers, diluents and excipents. |
